National statistics indicate that the overdose fatality rate has quadrupled since 1999, including a sharp uptick in 2013, coinciding with the proliferation of synthetic opioids like fentanyl. Over the past year, the COVID-19 pandemic has coincided with another surge in fatal overdoses. State health agencies can work to prevent overdoses by strengthening economic supports; identifying and supporting people at risk; implementing Prescription Drug Monitoring Programs; collaborating with hospital, healthcare, and emergency systems; distributing naloxone and using naloxone tracking and administration data to identify hot spots; expanding access to substance use treatment and supporting linkages to care; implementing mass media awareness campaigns; increasing the capacity of medical examiners, coroners, and toxicologists; supporting and providing education around public safety and first responders; and teaching coping and problem-solving skills. Using the Suicide, Overdose, and Adverse Childhood Experiences Prevention Capacity Assessment Tool (SPACECAT) can assist with determining your state's level of capacity to implement overdose prevention strategies. Below is a list of beginner, intermediate, and advanced actions your organization can take based on your SPACECAT results.